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Knicks vs Cavaliers Prediction, Picks & Odds for Tonight’s NBA Game

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The Cleveland Cavaliers return home to Rocket Arena to host the New York Knicks in a battle between two Eastern Conference powerhouses.

The Cavs acquired James Harden for games like this, and my Knicks vs. Cavaliers predictions expect a strong offensive showing. 

Read on for my NBA picks for Tuesday, February 24.

Knicks vs Cavaliers prediction

Knicks vs Cavaliers best bet: James Harden Over 18.5 points (-115)

James Harden is averaging 18.7 points per game with the Cleveland Cavaliers, shooting an efficient 50% from inside the arc and 47% from downtown, and he has a terrific matchup tonight. 

The New York Knicks don’t consistently trap high, and if they choose to guard him straight up, they’ll see a healthy diet of mid-range jumpers, pull-up threes, and layups.

Games like tonight are why the Cavs traded for Harden. They’ve lost two straight to the Knicks, but Harden is a wily and creative scorer, and I’m betting on a vintage scoring night from the veteran guard. 

Knicks vs Cavaliers same-game parlay

Karl-Anthony Towns leads the NBA in double-doubles and only needs a typical 22-10-3 line to clear his PRA combo prop.

Landry Shamet is averaging 13.7 points in 27 minutes since February 1, making 10 points a very reachable number.

Knicks vs Cavaliers SGP

  • James Harden Over 18.5 points
  • Karl-Anthony Towns Over 33.5 points + rebounds + assists
  • Landry Shamet Over 9.5 points

Our "from downtown" SGP: Cleveland rocks the house

Cleveland is deeper, healthier, and playing its best basketball at home. They are 8-2 straight up over their last 10 games and have more offensive firepower with Harden in the lineup.

Knicks vs Cavaliers SGP

  • James Harden Over 18.5 points
  • Karl-Anthony Towns Over 33.5 points + rebounds + assists
  • Landry Shamet Over 9.5 points
  • Cavaliers moneyline

Knicks vs Cavaliers odds

  • Spread: Knicks +4 (-105) | Cavaliers -4 (-115)
  • Moneyline: Knicks +150 | Cavaliers -180
  • Over/Under: Over 231.5 (-110) | Under 231.5 (-110)

Knicks vs Cavaliers betting trend to know

The Cleveland Cavaliers have hit the Moneyline in 14 of their last 17 games (+10.35 Units / 20% ROI). Find more NBA betting trends for Knicks vs. Cavaliers.

How to watch Knicks vs Cavaliers

LocationRocket Arena, Cleveland, OH
DateTuesday, February 24, 2026
Tip-off7:30 p.m. ET
TVPeacock

Knicks vs Cavaliers latest injuries

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