DraftKings lists Cleveland Browns defensive end Myles Garrett as the leading favorite for the 2026–27 Defensive Player of the Year, with odds of +425. Garrett finished the 2025 season with a league‑record 17.5 sacks, positioning him as a strong contender for a repeat award.
Other top contenders include Green Bay Packers' Micah Parsons (+800), Las Vegas Raiders' Maxx Crosby (+800), and Detroit Lions' Aidan Hutchinson (+800). New York Giants linebacker Brian Burns, who posted 16.5 sacks last season, is also a notable dark horse at +1200.