This win was as comfortable as Mikel Arteta would have hoped for before kick-off as his much-rotated side cruised through.
Bukayo Saka was able to get some minutes in midfield as he continues to build up his match fitness after recovering from a hip issue.
The 24-year-old has played in central areas for Arsenal before and appeared comfortable enough in midfield on Sunday, linking the play as the hosts dominated.
Cup competitions have been a happy place for Saka's fellow winger Gabriel Martinelli this season - and so it proved again.
The Brazil attacker has scored just once in the Premier League this term, but has now netted 10 times in 13 games in European and cup competitions.
Martinelli is also now the first player to score 10-plus goals in cup and European competitions in a single campaign for Arsenal since Ian Wright in 1994-95 (12).
The Gunners were also able to give home debuts to 16-year-old Marli Salmon in the second half as the young defender replaced William Saliba and 19-year-old goalkeeper Tommy Setford came on for Kepa Arrizabalaga.
Arteta used the occasion to try to give some squad members a confidence boost and much-needed minutes, including Eberechi Eze - who was substituted at half-time during Arsenal's draw with Brentford in midweek but added two quality assists against Wigan.
The win means Arsenal are still in four competitions as they look to end their six-year wait for a trophy.