The Boilermakers emphatically ended their two-game losing streak against the Hoosiers by producing their highest point total in the series since 1998 and their largest victory margin since 1969. Fletcher Loyer and Omer Mayer each added 18 points for Purdue.
Lamar Wilkerson scored 18 of his 20 points in the second half to lead Indiana, which lost its second straight to a top-10 team. The victory came three days after Purdue lost at home to top-ranked Michigan.