Arsenal are managing injuries to key players including Kai Havertz, William Saliba and Martin Ødegaard, with fringe players like Myles Lewis-Skelly, Ben White and Eberechi Eze tipped for involvement. Arteta's team, built on structure and depth, faces the challenge of efficiently progressing without exposing tired legs ahead of crucial league fixtures.
The head-to-head history heavily favors Arsenal, who have won sixteen of their meetings compared to Wigan's three. The clubs last met competitively in the 2014 FA Cup semi-final, which Arsenal won on penalties.